Can Naruto fight Madara?
The strongest enemy that Madara fought in the story was, undoubtedly, Naruto Uzumaki. Like Sasuke, Naruto was left in a near-death state by Madara Uchiha. However, thanks to Obito, he was rescued. Acquiring Six Paths powers, Naruto was able to take on and even overwhelm Madara Uchiha in combat.
One of the strongest shinobi to have ever existed, Naruto Uzumaki is one of the few characters in the entire series who could possibly defeat Madara Uchiha. During the 4th Great Ninja War, the two clashed for a long time and Naruto was, more or less, able to keep up with him without any significant problems.
Naruto is equipped with many weapons that would allow him to beat Madara, even in his Six Paths mode. The blonde Uzumaki has access to Kurama's Chakra, which is equivalent to half the Juubi's energy. He was also granted half of Hagoromo's power, including the use of Truth Seeking orbs.
Madara was great during his youth, able to keep up with Hashirama Senju (The First Hokage) and do major damage with his Susanoo. At the height of his power, he was able to slaughter entire groups of ninja, take on the Kage, and slice the tops of mountains off! Alone, Boruto wouldn't stand much of a chance.
Madara Uchiha is among the most powerful shinobi to have ever lived, and his power only increased when he attained the power of the Sage of the Six Paths. He was able to fend off both Naruto Uzumaki and Sasuke Uchiha for a time in this form, and Kakashi Hatake would likely be unable to subdue Madara on his own.
The series' protagonist happens to be the strongest Shinobi to ever exist in the Naruto universe. From Kurama Chakra to Sage Mode and later even Six Paths Sage Mode, he gains a lot of power as the show progresses. As such, it is only possible that he is one of the very few who can defeat Madara.
It is easy to see that Sasuke supplants Madara in every category except for chakra reserves as the latter was the jinchuriki of the Ten-Tails. However, Sasuke is far ahead in all the other categories. Consequently, Sasuke is undoubtedly the strongest Uchiha in Naruto.
By adulthood, Naruto has fought and defeated characters such as Momoshiki Otsutsuki, who is considered to be a God of the verse. To date, he remains the greatest ninja in the series, and so, he's undoubtedly stronger than Itachi.
However, despite all that he was capable of, Madara was openly stated to be much weaker than Kaguya Otsutsuki. He doesn't stand a chance against Naruto Uzumaki in his Baryon Mode.
Although Naruto lost Kurama, his Six Paths Powers should still be accessible to him. In Naruto's fight against Madara, he displayed the ability to use Six Paths Sage Mode without tapping into the power of the chakra cloak. The Six Paths chakra should be enough to keep him going for a few years.
Is anybody stronger than Naruto?
Shibai Otsutsuki is, by far, the strongest character to ever appear in the story and, for him, dealing with someone as strong as Naruto wouldn't be an issue at all. Even if Naruto had not lost Kurama, his powers would still be inferior to Shibai Otsutsuki.
Obito becomes the Ten-Tails host but is defeated by Naruto and Sasuke with the support of the Allied Shinobi Forces.

Even though Boruto's body isn't fully Otsutsukified, Momoshiki Otsutsuki remains far stronger than Naruto without the aid of Kurama.
Although the two have never fought, the fact that Tsunade struggled against Madara Uchiha and Sasuke demolished a stronger version of him is enough to point out that he's much stronger.
Sasuke is yet another strong character in the Naruto series who eventually surpassed Kakashi. Sasuke was so strong that he was able to perform jutsus like Indra's Arrow which has similar, if not the same destructive capabilities compared to Naruto's Six Paths: Ultra Big Ball Rasenshuriken.
Naruto Surpassed His Beloved Mentor
Coming to terms with his jinchuriki would render him immune to whatever genjutsu Jiraiya could hope to confront him with. Moreover, since Naruto can harness sage chakra better than his master, prolonging the fight would only serve to his advantage.
1) Hashirama Senju
Hashirama united the Senju and Uchiha clans and went on to establish Konohagakure. He was unmatched in power during his lifetime and even after death. Hashirama was undefeated in his lifetime.
Naruto defeats Pain with his final Rasengan, removing his Chakra Receivers before heading to Nagato's location, having Katsuya tell the others not to follow as Sakura finishes healing Hinata. Naruto encounters Inoichi and Shikaku on the way, the latter honoring Naruto's request to stand down to Inoichi's dismay.
The biggest rival of Madara Uchiha, Hashirama was the First Hokage of Konohagakure. Having grown up together, the two shared quite a great bond with each other, however, it worsened over time. They fought several times throughout their lifetime and Hashirama is known to have won most of them.
1 CAN'T BEAT: Madara Uchiha
To defeat such a character, one would have to possess the powers of a God itself. Unfortunately for Sakura, she doesn't have any such power. Her strength pales in comparison to Madara's, and so does everything else about her.
Who is stronger Madara or Obito?
After Sasuke, Madara is undoubtedly the strongest known Uchiha in the history of the series. Like Obito, he became the 10 Tails Jinchūriki in the Fourth Great Ninja War. Madara was much stronger than Obito to begin with, and the fact that his version of the Ten-tails was perfect made him even stronger.
Gaara and Naruto have an epic battle with Gaara taking his Shukaku form and Naruto summoning Gamabunta and taking the form of the nine tailed fox. Naruto finally beats Gaara and in beating him makes Gaara realize killing people isn't what he needs to do to confirm his existence and Naruto befriends him.
Kakashi does battle Itachi early in the series. Itachi ends up trapping him in a genjutsu and draining Kakashi. The contest basically ends up in a loss for Kakashi, but that is somewhat debatable. Still, Itachi shows more control over his Sharingan and the ability to match Kakashi.
When it comes to physical strength, there's no doubt that Naruto has surpassed the Fourth Hokage. Although Minato was quite powerful himself, he had his limits as a ninja. As the Nine-Tails Jinchuriki, Naruto had access to two types of chakra for most of his life which granted him increased durability and strength.
As such, once Naruto transformed into the Sage of Six Path mode, his basic abilities were enhanced to a state where he could almost move at the speed of light. In fact, his special ability Wind Style Rasenshuriken when combined with Tailed Beast Bomb would become strong enough to lethally injure Madara.
Naruto would literally one shot the entire demon slayer verse with one attack. He could. Demon Slayer verse top tiers were MHS+ and Multi City Block. that's completely fodder to even Shippuden let alone Boruto series whom Naruto has shown Planet level scaling and Star level scaling.
Since Naruto mainly relies on ninjutsu, Meliodas can easily beat him. In fact, no matter how much damage Naruto causes, Meliodas could always use Full Counter and knock him out easily.
Although Naruto lost Kurama, he still has access to the powers of the other Tailed Beasts. During the Fourth Great Ninja War, he received a portion of the chakra of every Tailed Beast and has utilized this power to a great degree in all his fights since.
Despite the loss of his dear friend, the Seventh Hokage can still use the Sage Mode. Fans were delighted to see that Naruto still retained some of his powers and that he is capable of taking down strong opponents. However, he had to use Shadow Clones in order to collect the natural energy.
In Boruto, Kurama did die, but he can be revived because Naruto has his chakra mixed with the Kyuubi after spending so many years without any seal. Reviving Kurama is only possible because Naruto's got power of six paths light which gives him the power to revive beings, organs, known as Yin Yang Release.
Can obito defeat Naruto?
Obito becomes the Ten-Tails host but is defeated by Naruto and Sasuke with the support of the Allied Shinobi Forces.
Naruto Uzumaki
Naruto was powerful enough to fight Obito Uchiha, Madara Uchiha, Kaguya Otsutsuki, and then Sasuke Uchiha all in one day. As such, there's no way Itachi is stronger than him.